| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for efficiently standing projections of micrometer size in a high degree of integration within a short time in order to supply a product of patch type to the society, although a fine needle-like or thread-like percutaneous absorption preparation as a preparation technology for ameliorating the absorption of a medicine having poor or low absorption from the skin after percutaneous administration and improving bioavailability was previously invented by Takada. SOLUTION: The method for producing a patch having conical projections of several hundred micrometers comprises making scores or several hundreds of inverted conical pores per block (1 square centimeter) on the base of a silicone resin or thermoplastic resin, forcing a concentrated solution or admixture composed of a medicine, an additive or a base into the pores under pressure, carrying out drying while forcing the concentrated solution and peeling a self-adhesive tape, to stand conical projections having a height of 100-500 micrometers and a bottom diameter of 100-500 micrometers on the patch. COPYRIGHT: (C)2009,JPO&INPIT
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