A heat-resistant water soluble derivative of urokinase is prepared which comprises urokinase covalently bonded to a copolymer of acrylamide and acrylic acid having a molecular weight of 10,000 to 200,000 and a content of acrylic acid of 1% to 2%. The derivative contains 15% to 35% urokinase and has an esterase and amidolytic activity of from 10% to 80%.
申请公布号
US4349630(A)
申请公布日期
1982.09.14
申请号
US19800183093
申请日期
1980.08.27
申请人
MAXIMENKO, ALEXANDR V.;TORCHILIN, VLADIMIR P.;SMIRNOV, VLADIMIR N.;CHAZOV, EVGENY I.
发明人
MAXIMENKO, ALEXANDR V.;TORCHILIN, VLADIMIR P.;SMIRNOV, VLADIMIR N.;CHAZOV, EVGENY I.