MODIFIED NUCLEOSIDES FOR RNA INTERFERENCE

摘要

The present invention relates to the use of modified nucleotides and single or double stranded oligonucleotides comprising at least one of said modified nucleotides for performing RNA interference. The modified nucleotides are selected from 6-membered ring containing nucleotides such as hexitol, altritol, O-subsituted or O-alkylated altritol, cyclohexenyl, ribo-cyclohexenyl and O-subsituted or O-alkylated ribo-cyclohexenyl nucleotides. The present invention also relates to novel modified nucleosides or nucleotides and to the use of said novel modified nucleosides and nucleotides in single or double stranded oligonucleotides for RNA interference, antisense therapy or other applications.