发明名称 |
Multimerization of HIV-1 vif protein as a therapeutic target |
摘要 |
The HIV-1 protein Vif comprises a multimerization domain that allows Vif-Vif interaction and Vif multimerization, which is important for Vif function in the HIV-1 life-cycle. A method for screening for an antagonist of Vif comprises contacting the multimerization domain of Vif with a test compound that specifically binds the multimerization domain. Antagonists identified by the screening assay inhibit Vif multimerization. The antagonists inhibit essential functions of Vif and accordingly are useful as inhibitors of HIV-1 replication.
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申请公布号 |
US2008167199(A1) |
申请公布日期 |
2008.07.10 |
申请号 |
US20070809953 |
申请日期 |
2007.06.04 |
申请人 |
THOMAS JAFFERSON UNIVERSITY |
发明人 |
ZHANG HUI;POMERANTZ ROGER J.;YANG BIN |
分类号 |
C40B30/04;G01N33/50;A61K38/00;A61K39/395;A61P31/12;A61P31/18;C07K7/04;C07K14/16;C07K16/08;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
C40B30/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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