| 摘要 |
The present invention provides user-directed construction of novel specif ic homo- and hetero-dimeric, and multimeric assemblages of proteins. The pre sent invention is comprised of gene sequences that transcribe peptide sequen ces that form links between proteins, where the peptide sequences produce a hook or loop which supports specific self-assembly of homo-dimers, hetero-di mers and multimers of the proteins to which they are attached. The hook or l oop may have a short aliphatic repeat sequence and a metal binding loop. The present invention also provides a method of constructing a hook motif of me tal binding loop sequences that may be attached to at least one aliphatic re peat sequence to produce the assemblages of proteins. Also provided are prot ein structures produced by the methods of the present invention.
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