发明名称 |
SCREENING FOR ANTI-CANCER COMPOUNDS USING NETRIN-1 ACTIVITY |
摘要 |
The subject matter of the present invention relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compound to interact with netrin-1 receptor and/or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The invention also relates to a method for predicting the presence of metastatic or aggressive cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of netrin-1. The invention further comprises kits and compounds as a medicament for the treatment of cancer such as metastatic breast cancer, related to the overexpression of netrin-1 by the tumor cells. |
申请公布号 |
EP1989546(A1) |
申请公布日期 |
2008.11.12 |
申请号 |
EP20070726556 |
申请日期 |
2007.02.28 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);CENTRE LEON BERARD |
发明人 |
MEHLEN, PATRICK;BERNET, AGNÈS;FITAMANT, JULIEN |
分类号 |
A61K38/18;A61K39/00;C07K16/22;C07K16/28;C12Q1/18;C12Q1/68;G01N33/50;G01N33/566;G01N33/574 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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