DIAGNOSIS AND TREATMENT OF INFLAMMATORY BOWEL DISEASE IN THE PUERTO RICAN POPULATION
摘要
<p>This invention provides methods of diagnosis and treatment of inflammatory bowel disease. In one embodiment, the invention provides methods of diagnosing and/or predicting susceptibility for inflammatory bowel disease in the Puerto Rican population by determining the presence or absence of a risk variant at the HPS1 locus. In another embodiment, the invention further provides methods of diagnosing and/or predicting protection against inflammatory bowel disease by determining the presence or absence of a protective variant at the IRF1 locus. In another embodiment, the presence in an individual of a risk variant at the CARD8 locus is diagnostic of susceptibility to Crohn's Disease in a Puerto Rican individual. In another embodiment, the presence of a risk variant at the TLR-9 locus in an individual is diagnostic of susceptibility to Crohn's Disease.</p>
申请公布号
WO2008134569(A2)
申请公布日期
2008.11.06
申请号
WO2008US61652
申请日期
2008.04.25
申请人
CEDARS-SINAI MEDICAL CENTER;UNIVERSITY OF PUERTO RICO;ROTTER, JEROME, I.;TAYLOR, KENT, D.;TORRES, ESTHER, A.
发明人
ROTTER, JEROME, I.;TAYLOR, KENT, D.;TORRES, ESTHER, A.