SUBSITUTED SULPHONAMIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND THEIR USE

摘要

Substituted sulphonamides having the general formula (I) and salts, hydra tes and solvates thereof were prepared and described, wherein R1 isCO or SO2 and R2 is NH or O and where R represents linear or cyclic aliphatic chain a nd n represents number of linking aliphatic chain carbons (n can be 0, 1, 2 or 3), which are useful in the manufacture of the medicaments due to the car boanhydrase inhibition. These compounds are prepared by nucleophilic reactio n of an amine with 4-sulfamoylbenzenesulphonyl chloride in the presence of t riethylamine excess in tetrahydrofurane or in ether at temperature 0 to 20 ° C. The compounds show an antiglaucomatic activity.