| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a transdermal administration device which shows a relieved skin irritation at the application, particularly at the peeling, and enables the continuous administration of a therapeutically or preventively effective amount of bisoprolol to a living body. <P>SOLUTION: The transdermal administration device 10 for bisoprolol is equipped with a supporting medium 1 and a pressure-sensitive adhesive layer 2 which is layered on one surface of the supporting medium 1 and contains bisoprolol in the pressure-sensitive adhesive layer 2. The maximum speed of releasing bisoprolol within 24 hours immediately after the application to the skin is not higher than 30μg/cm<SP>2</SP>/hour, and the speed of releasing bisoprolol at the point 24 hours after the application to the skin is not higher than 10μg/cm<SP>2</SP>/hour. Thus, not only the skin irritation by bisoprolol is restrained, but also the possibility of side effects such as bradycardia or dizziness by excessive antihypertension are excluded, ensuring sufficient safety. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
