发明名称 |
TREATMENT OF B CELLS WITH IL-21 AND B CELL ACTIVATORS INDUCES GRANZYME B PRODUCTION |
摘要 |
The present invention involves the combined use of IL-21 and TLR agonists such as CpG oligonucleotides in the treatment of B cell cancers and B cell-related immune pathologies such as autoimmune diseases. In addition, it is demonstrated that human B cells produce and secrete varying amounts of Granzyme B in response to IL-21 depending on their activation state, and at the same order of magnitude as those secreted by cytotoxic T lymphocytes. In CpG ODN-treated B-CLL cells, Granzyme B secretion in response to IL-21 can be cytotoxic. |
申请公布号 |
WO2007030602(A3) |
申请公布日期 |
2008.10.02 |
申请号 |
WO2006US34829 |
申请日期 |
2006.09.07 |
申请人 |
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION;WEINER, GEORGE;JAHRSDOERFER, BERND |
发明人 |
WEINER, GEORGE;JAHRSDOERFER, BERND |
分类号 |
A61K45/00;A61K31/70 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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