发明名称 |
N-SUBSTITUTED PEPTIDOMIMETIC INHIBITORS OF DIPEPTIDYLPEPTIDASE IV |
摘要 |
One aspect of the present invention relates to inhibitors of post-pro line protease enzymes, such as inhibitors of dipeptidyl peptidase IV (DPIV). Other aspects of the invention relate to pharmaceutical compositions and methods of use thereof. In certain embodiments, a DPIV inhibitor comprises a carboxylic acid-containing side chain moiety at the P1 or P2 position or both. The inhibitors of the invention should possess improved specificity for the targeted protease and low toxicity. |
申请公布号 |
WO2008118848(A1) |
申请公布日期 |
2008.10.02 |
申请号 |
WO2008US58003 |
申请日期 |
2008.03.24 |
申请人 |
TRUSTEES OF TUFTS COLLEGE;BACHOVCHIN, WILLIAM, W.;LAI, HUNG-SEN |
发明人 |
BACHOVCHIN, WILLIAM, W.;LAI, HUNG-SEN |
分类号 |
A61K31/66;A61K31/69;A61K38/00 |
主分类号 |
A61K31/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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