| 摘要 |
Disclosed is an excellent prophylactic and/or therapeutic agent for diabe tic neuropathy, which comprises a 2-[(substituted-indene-7-yloxy)methyl]morp holine represented by the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The prophylactic and/or therapeutic agent i s particularly useful as a prophylactic and/or therapeutic agent for diabeti c motor nerve disorder (e.g., decrease in muscular strength (decrease in mus cular strength to an extent of being unable to independently walk)), diabeti c sensory nerve disorder (paresthetic (abnormal vibratory sensation), allody nia, reduced sensation (numbness in limbs, psychroesthesia) or pain), or dia betic autonomic nerve disorder (e.g., abnormal bowel habituation such as con stipation and diarrhea, urinary dysfunction, impotence, orthostatic hypotens ion, dyshidrosis, abnormal heart rate variability, delayed gastric emptying) . Also disclosed is an ameliorating gent for a disease condition of diabetic nerve disorder.
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