INFLAMMATION TREATMENT, DETECTION AND MONITORING VIA TREM-1

摘要

The present invention provides methods of treating inflammatory diseases/disorders in a subject by inhibiting/antagonizing TREM-1 expression/activity/signal transduction and/or DAP12/TyroBP expression and/or activity. Methods of detecting the presence of inflammatory disease in a subject by detecting TREM-1 and/or DAP12/TyroBP expression and/or activity in the subject or a sample obtained therefrom, wherein increased expression or activity is indicative of the inflammatory disease are also included. The present invention further provides methods for assessing the efficacy of a TREM-1 -modulating agent administered to a patient by detecting levels of secreted phosphoprotein 1 (SPPl) and/or one or more other biomarkers in the patient or in a sample from the patient.