Sustained-Released Pellet Formulation of Alpha1-Receptor Antagonist and Process For the Preparation Thereof

摘要

A sustained-release pellet formulation comprising: a pellet core comprising an alpha1-receptor antagonist, a pellet-forming substance and a pharmaceutically acceptable excipient and a coating layer comprising an enteric coating substance and a water-insoluble polymer, which is coated on said pellet core maintains a therapeutically effective drug level in the blood for a sufficient time without an initial burst and sustains the release of the drug even in the small intestine due to the water-insoluble polymer in the coating layer