| 发明名称 |
Selective Alfavbetas Receptor Peptide Antagonist for Therapeutic and Diagnostic Applications |
| 摘要 |
The present invention is related to new peptide antagonists of alpha<SUB>v</SUB>beta<SUB>3 </SUB>receptor, designed on the basis of the crystal structure of integrin alpha<SUB>v</SUB>beta<SUB>3 </SUB>in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the alpha<SUB>v</SUB>beta<SUB>3 </SUB>receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for alpha<SUB>v</SUB>beta<SUB>3</SUB>-targeted therapy and imaging. |
| 申请公布号 |
US2008213190(A1) |
申请公布日期 |
2008.09.04 |
| 申请号 |
US20060089709 |
申请日期 |
2006.10.09 |
| 申请人 |
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发明人 |
DEL GATTO ANNARITA;ZACCARO LAURA;PEDONE CARLO;SAVIANO MICHELE |
| 分类号 |
A61B5/055;A61K38/12;C07K14/00 |
主分类号 |
A61B5/055 |
| 代理机构 |
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代理人 |
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