摘要 |
This invention is directed to methods for preventing, treating, reversing, inhibiting, or arresting epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof,: Formula (I) Formula (II) wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R-i, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and CrC4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, CrC4 alkyl, CrC4 alkoxy, amino, nitro and cyano). |
申请人 |
JANSSEN PHARMACEUTICA, N.V;TWYMAN, ROY, E.;ZHAO, BOYU |
发明人 |
TWYMAN, ROY, E.;ZHAO, BOYU |