发明名称 |
Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's |
摘要 |
The invention provides a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein: R1 is 2,6-dichlorophenyl; R2a and R2 are both hydrogen; and R3 is a group: where R4 is C1-4 alkyl. The compounds have activity as inhibitors of CDK kinases and inhibit the proliferation of cancer cells.
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申请公布号 |
US2008139620(A1) |
申请公布日期 |
2008.06.12 |
申请号 |
US20060814449 |
申请日期 |
2006.01.20 |
申请人 |
ASTEX THERAPEUTICS LIMITED |
发明人 |
WYATT PAUL GRAHAM;BERDINI VALERIO;GILL ADRIAN LIAM;TREWARTHA GARY;WOODHEAD ANDREW JAMES |
分类号 |
C07D401/12;A61K31/454;A61P35/00;C12N5/00 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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