ANTIFUNGAL PEPTIDE, PEPTIDE COMPOSITION CONTAINING THE SAME AND METHOD FOR PRODUCING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a peptide exhibiting proliferation-inhibiting activities against fungi.

SOLUTION: The antifungal agent contains a peptide comprising the following amino acid sequence: (sequence number 1) Ile Arg Arg Arg Arg Pro Arg Arg; (sequence number 2) Ser Arg Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg; (sequence number 3) Val Ser Arg Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg; (sequence number 4) Arg Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg; (sequence number 5) Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg; or (sequence number 6) Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg, or a salt thereof, or a fragment of them as an active ingredient. The peptide is prepared by hydrolyzing protamine. The prepared peptide composition can be utilized in wide applications because of having excellent antifungal activities, and being excellent in safety aspect because the peptide is originated from a natural product.

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