摘要 |
A compound having the structure : wherein R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB>, R<SUB>6</SUB>, R<SUB>7</SUB> and R<SUB>9</SUB> are independently hydrogen, C<SUB>1 </SUB>to C<SUB>6</SUB> alkyl or substituted alkyl, halogen, sulfate or glucuronide moieties; the ---- symbol represents either a single or a double bond and when the ---- symbol is a double bond and forms a keto group at position 3 or 17, then no R<SUB>7</SUB> or R<SUB>6 </SUB>is present, respectively; the symbol --- represent the presence or absence of a bond at position 10; and the ~~~ symbol represents any type of bond regardless of the stereochemistry. The invention also embraces the enantiomers, other stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of said compounds. |