HIGH AFFINITY ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR ALPHA 1

摘要

High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13R.alpha.l- mediated activities and, accordingly, present desirable anta gonists for the use in the treatment of conditions associated with hIL-13R.a lpha.l activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising th e antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13R.alpha.l-mediated activities are also disclosed.