发明名称 |
Antiviral inhibition of capsid proteins |
摘要 |
Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a compound that binds to the apical cleft near the C-terminal end of the N-terminal domain of the HIV-1 capsid protein are provided. Derivatives of CAP-1, CAP-2, CAP-3, CAP-4, CAP-5, CAP-6 and CAP-7 are described that bind to the apical cleft of the N-terminal domain of the HIV-1 capsid protein and inhibit proper assembly of the core particle.
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申请公布号 |
US7361459(B2) |
申请公布日期 |
2008.04.22 |
申请号 |
US20030420438 |
申请日期 |
2003.04.22 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY |
发明人 |
SUMMERS MICHAEL F.;TANG CHUN;HUANG MINGJUN |
分类号 |
C12Q1/70;G01N33/50;A61K31/00;A61K31/17;A61K31/277;A61K31/341;A61K39/21;A61K45/00;A61P31/18;A61P43/00;C07C275/30;C07C275/32;C07C275/40;C07C275/42;C07C281/06;C07D307/52;C07K14/16;C12Q1/18;G01N33/15;G06F19/00;G06F19/16 |
主分类号 |
C12Q1/70 |
代理机构 |
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