| 摘要 |
The present invention relates to neukinase, a downstream protein kinase i n the neuregulin signaling pathway. In certain aspects, the present inventio n provides isolated neukinase-encoding nucleic acids, neukinase polypeptides , oligonucleotides that hybridize to neukinase nucleic acids, and expression vectors containing neukinase-encoding sequences. The present invention furt her provides isolated host cells, antibodies, transgenic non-human animals, compositions, and kits relating to neukinase. In other aspects, the present invention further provides methods of identifying predisposition to cardiac dysfunction, methods of detecting the presence of neukinase, neukinase nucle ic acid, methods of screening for agents which affect neukinase activity, an d methods of modulating neukinase activity. |
