CONTROLLED RELEASE ORAL DOSAGE FORMULATIONS COMPRISING A CORE AND ONE OR MORE BARRIER LAYERS

摘要

Controlled release oral dosage formulations containing one or more active agent, and methods of use thereof, are provided for the once-a-day treatmen t. The formulation can be in the form of a trilayer tablet containing a core or central layer and one or more barrier layers. The core may contain one o r more enteric materials or polymeric materials which modulates the release of the active agent.