发明名称 |
Gene disruptions, compositions and methods relating thereto |
摘要 |
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. |
申请公布号 |
ZA200606461(B) |
申请公布日期 |
2008.02.27 |
申请号 |
ZA20060006461 |
申请日期 |
2005.01.27 |
申请人 |
LEXICON PHARMACEUTICALS, INC |
发明人 |
EDWARDS, JOEL;HUANG, WENHU;MONTGOMERY, CHARLES;QIAN, NI NANCY;SHI, ZHENG-ZHENG;SPARKS, MARY JEAN;VOGEL, PETER;WESTBROOK, MINDY |
分类号 |
A01K;C07K;C07K14/47 |
主分类号 |
A01K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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