发明名称 |
Fusion protein of porcine reproductive and respiratory syndrome virus as PRRS vaccine |
摘要 |
<p>The present invention provides a PRRSV subunit vaccine comprising a fusion protein having neutralization titers evoked, PE-PQGAB-K3, which comprises a chimeric polypeptide containing N-terminal portions of PRRSV ORF5 and ORF6 structure proteins; a portion of Pseudomonas exotoxin A binding and translocation domain; and a carboxyl terminal domain containing KDEL-KDEL-KDEL(K3) sequence. Less inflammation of PE-PQGAB-K3 vaccine group in their lungs post being PRRSV-challenged indicates that PQGAB without an antigen-specific allergy effect. Importantly, PE-PQGAB-K3 vaccine presents a good protection against PRRSV infection than control groups in pig challenged experiment.</p> |
申请公布号 |
EP1882478(A1) |
申请公布日期 |
2008.01.30 |
申请号 |
EP20060253982 |
申请日期 |
2006.07.29 |
申请人 |
HEALTHBANKS BIOTECH CO., LTD. |
发明人 |
CHANG, HSIU-KANG;LIAO, CHAO-WEI |
分类号 |
A61K39/12;C07K14/08;C07K19/00 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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