ПИПЕРИДИНАМИНОБЕНЗИМИДАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ КАК ИНГИБИТОРЫ РЕПЛИКАЦИИ РЕСПИРАТОРНОГО СИНЦИТИАЛЬНОГО ВИРУСА

摘要

The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is C_1-6alkyl optionally substituted with trifluoromethyl, C_3-7cycloalkyl, Ar², hydroxy, C_1-4alkoxy, C_1-4alkylthio, Ar²-oxy-, Ar²-thio-, Ar²(CH₂)_noxy, Ar²(CH₂)_nthio, hydroxycarbonyl, aminocarbonyl, C_1-4alkyl-carbonyl, Ar²-carbonyl, C_1-4alkoxycarbonyl, Ar²(CH₂)_ncarbonyl, aminocarbonyloxy, C_1-4alkylcarbonyloxy, Ar²-carbonyloxy, Ar²(CH₂)_ncarbonyloxy, C_1-4alkoxy-carbonyl(CH₂)_noxy, mono- or di(C_1-4alkyl)aminocarbonyl, mono- or di(C_1-4alkyl)-aminocarbonyloxy, aminosulfonyl, mono- or di(C_1-4alkyl)aminosulfonyl or a heterocycles selected from the group consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, pyridyl and tetrahydropyridyl, wherein each of said heterocycle may optionally be substituted with oxo or C_1-6alkyl; G is a direct bond or optionally substituted C_1-10alkanediyl; R¹ is Ar¹ or a monocyclic or bicyclic heterocycle; one of R^2a and R^3a is C_1-6alkyl and the other one of R^2a and R^3a is hydrogen; in case R^2a is different from hydrogen then R^2b is hydrogen or C_1-6alkyl, and R^3b is hydrogen; in case R^3a is different from hydrogen then R^3b is hydrogen or C_1-6alkyl, and R^2b is hydrogen; t is 1, 2 or 3; Ar¹ is phenyl or substituted phenyl; and Ar² is phenyl or substituted phenyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.