METHOD FOR RADIOLABELING FORMULATIONS FOR GAMMA SCINTIGRAPHY ASSESMENT

摘要

The present invention is directed to a novel method for producing a radiolabeled product for use in gamma scintigraphy, preferably for use with gastric retentive formulations. One aspect of the invention is the process which comprises adsorbing a suitable radionuclide onto a substrate, such as activated charcoal, and blending this nuclide/substrate product with an insoluble polymer; forming a melt blend of the polymer mix, cooling the melt blend to form a solid, and then breaking the solid into smaller particles. Suitably, the temperature of the melt blend is high enough to melt the polymer but not enough to degrade the polymeric material.