发明名称 |
CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE |
摘要 |
The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with actin polymerization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or II, wherein said amount is effective to influence the cytoskeleton, for example by inhibiting actin polymerization.
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申请公布号 |
KR20070116019(A) |
申请公布日期 |
2007.12.06 |
申请号 |
KR20077021994 |
申请日期 |
2007.09.21 |
申请人 |
INSPIRE PHARMACEUTICALS, INC. |
发明人 |
LAMPE JOHN W.;PLOURDE ROBERT JR.;SHE JIN;VITTITOW JASON L.;WATSON PAUL S.;CRIMMINS MICHAEL T.;SLADE DAVID J. |
分类号 |
C07D417/04;C07D491/08;C07D493/08;C07D498/08 |
主分类号 |
C07D417/04 |
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