发明名称 |
An animal model for identifying a common stem/progenitor to liver cells and pancreatic cells |
摘要 |
<p>The invention provides animal models, where the ectopic expression of KGF, EGF, or both is under the control of a pancreas-specific promoter, e.g., the insulin promoter. The expression of KGF in the ins-KGF pancreatic islets of Langerhans results in enlarged islets, with substantial proliferation of duct cells within the islet mass, and the presence of albumin and alpha-fetoprotein-producing hepatocytes in the islets of the ins-KGF pancreata. The compositions and methods disclosed are useful for identifying and isolating pancreatic stem/progenitor cells, including a common stem/progenitor to liver cells and pancreatic cells.</p> |
申请公布号 |
EP1857546(A1) |
申请公布日期 |
2007.11.21 |
申请号 |
EP20070015300 |
申请日期 |
1999.12.13 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
SARVETNICK, NORA;KRAKOWSKI, MICHELLE L.;KRITZIK, MARCIE R. |
分类号 |
C12N5/10;A01K67/027;A61K38/00;A61K38/18;A61K39/00;A61K39/395;A61K48/00;A61P1/16;A61P1/18;A61P3/00;C07K16/18;C12N1/00;C12N5/071;C12N5/074;C12N15/09;C12N15/85;C12Q1/02;C12Q1/68;G01N33/53;G01N33/68 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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