发明名称 |
HCV CORECEPTOR AND METHODS OF USE THEREOF |
摘要 |
<p num="1">The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.</p> |
申请公布号 |
CA2649962(A1) |
申请公布日期 |
2007.11.15 |
申请号 |
CA20072649962 |
申请日期 |
2007.05.04 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
RICE, CHARLES;VON HAHN, THOMAS;EVANS, MATTHEW J. |
分类号 |
C07K14/705;A61K39/395;A61K45/00;A61P31/14;C07K16/28;C12N5/10;C12N15/85;C12N15/86;C12Q1/68;G01N33/566 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|