发明名称 |
Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases |
摘要 |
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis and to an inflammatory reaction magnifying the damage, by the isolated or joint effect of inhibitors of the alanyl amino peptidase (APN) and of the dipeptidyl peptidase N (DP IV). Our results show that the application of inhibitors of the above-referenced enzymes or of preparations and dosage forms containing such inhibitors is definitely suitable for a therapy and prevention of dementia diseases and conditions.
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申请公布号 |
US7291599(B2) |
申请公布日期 |
2007.11.06 |
申请号 |
US20040916176 |
申请日期 |
2004.08.11 |
申请人 |
KEYNEUROTEK AG |
发明人 |
STRIGGOW FRANK;ROHNERT PETER;MACK TILL |
分类号 |
A61K31/40;A61K31/00;A61K31/165;A61K31/425;A61K38/05;A61K38/08;A61P25/16 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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