发明名称 |
DETECTION AND AMPLIFICATION OF LIGANDS |
摘要 |
A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
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申请公布号 |
US2007243593(A1) |
申请公布日期 |
2007.10.18 |
申请号 |
US20070751108 |
申请日期 |
2007.05.21 |
申请人 |
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发明人 |
WOOLVERTON CHRISTOPHER J.;NIEHAUS GARY D.;DOANE KATHLEEN J.;SCHMIDT STEVEN P.;SIGNS STEVEN A. |
分类号 |
C12M1/34;C12M1/00;C12N11/00;C12N11/02 |
主分类号 |
C12M1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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