发明名称 |
Multicomponent conjugates which bind to target molecules and stimulate T cell lysis |
摘要 |
The invention relates to immunoconjugates of formula: <?in-line-formulae description="In-line Formulae" end="lead"?>A-B-(C)<SUB>n </SUB><?in-line-formulae description="In-line Formulae" end="tail"?> where B may be present or absent, A is a specific binding protein such as an antibody or an antibody binding fragment, or a ligand binding to a receptor present on target cells B comprises at least one molecule to which "A" and "C" bind, such as an avidin/streptavidin complex, "C" is an MHC molecule, and "n" is a whole number ranging from 1 to 10. The conjugates provide the exquisite binding specificity of antibodies, combined with an ability to stimulate cytotoxic T cells to identify and to destroy cells on which the conjugate is bound and oligomerized. The conjugates are useful both therapeutically and diagnostically.
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申请公布号 |
US2007237771(A1) |
申请公布日期 |
2007.10.11 |
申请号 |
US20070804945 |
申请日期 |
2007.05.21 |
申请人 |
DONDA ALENA;MACH JEAN-PIERRE;CESSON VALERIE;ROBERT BRUNO;ROMERO PEDRO;LEUSCHER IMMANUEL;GUILLAUME PHILIPPE |
发明人 |
DONDA ALENA;MACH JEAN-PIERRE;CESSON VALERIE;ROBERT BRUNO;ROMERO PEDRO;LEUSCHER IMMANUEL;GUILLAUME PHILIPPE |
分类号 |
A61K39/395;A61K38/16;A61P35/00;C07K14/00;C07K16/00;C07K16/28;C07K16/30;C07K16/32;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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