SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES
摘要
<p>The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.</p>
申请公布号
CA2644474(A1)
申请公布日期
2007.09.13
申请号
CA20072644474
申请日期
2007.03.05
申请人
CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人
WANG, PIN;KWON, INCHAN;TANG, YI;SON, SOOJIN;TIRRELL, DAVID A.