A TOPICAL COMPOSITION COMPRISING EXTRACT OF ARDISIA CRENATA SHOWING SKIN WHITENING ACTIVITY

摘要

A topical composition comprising the extract of Ardisia crenata showing skin whitening activity is provided to inhibit tyrosinase activity and melanin production, and improve safety to the skin and storage stability. The topical pharmaceutical or cosmetic composition comprises 0.001-90 wt.%, preferably 0.01-10 wt.% of the extract of Ardisia crenata which shows skin whitening activity and is prepared by extracting Ardisia crenata with at least one solvent selected from water, ethanol, methanol, propanol, butanol, acetone, ethylacetate, hexane, butyleneglycol, propyleneglycol, hydrous butyleneglycol, hydrous propyleneglycol and hydrous glycerin at 50-100 deg.C for 2-5 hours or at 5-37 deg.C for 1-3 days. A daily dosage of the composition is 0.0001-100 mg/kg, preferably 0.001-10 mg/kg, and the cosmetic composition further comprises at least one substance selected from water-soluble vitamins, useful vitamins, polymer peptides, polymer polysaccharides, spingolipid and seaweed extract.