发明名称 |
Molecular torches and their use under denaturing conditions |
摘要 |
The present invention features "molecular torches" and the use of molecular torches for detecting the presence of a target nucleic acid sequence. Molecular torches contain a target binding domain, a target closing domain, and a joining region. The target binding domain is biased towards the target sequence such that the target binding domain forms a more stable hybrid with the target sequence than with the target closing domain under the same hybridization conditions. The joining region facilitates the formation or maintenance of a closed torch.
|
申请公布号 |
US7252947(B2) |
申请公布日期 |
2007.08.07 |
申请号 |
US20050044090 |
申请日期 |
2005.01.27 |
申请人 |
GEN-PROBE INCORPORATED |
发明人 |
BECKER MICHAEL M.;SCHROTH GARY P. |
分类号 |
C12N15/09;C12Q1/68;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|