| 摘要 |
1,274,453. Bronchodilatories containing prostaglandin compounds. AMERICAN HOME PRODUCTS CORP. 17 July, 1969 [2 Aug., 1968], No. 35985/69. Heading A5B. [Also in Division C2] Bronchodilatory compositions for administration by inhalation comprise a prostaglandin compound of formula wherein (i) G is C=O, X is a trans-double bond and Y and Z are single bonds; (ii) G is C=O and X, Y and Z are single bonds; (iii) H G is C# , X is a trans-double bond and OH Y and Z are single bonds; (iv) G is C=O, X is a trans-double bond and Y and Z are cis- H double bonds; or (v) G is C< , X is a OH trans-double bond and Y and Z are cis-double bonds; wherein R is hydrogen or C 1-6 alkyl, alkali metal or a pharmacologically acceptable cation derived from ammonia or a basic amine, and a liquid pharmacologically-acceptable carrier. Non-pressurized nebulizers contain the bronchodilatory composition in the form of an aqueous solution optionally containing additives to stabilize the solution and/or to provide an isotonic medium. Pressurized nebulizers contain a self-propelled bronchodilatory composition containing a pharmaceutically acceptable propellant in liquid form (e.g. dichlorodifluoromethane or a mixture of dichlorodifluoromethane and dichlorotetrafluoro ethane) and optionally a co-solvent (e.g. ethanol) or dispersing agent. Preferred prostaglandin compounds include 7 - [3 - hydroxy - 2 - (3 - hydroxy - 1 - octenyl) - 5 - oxocyclopentyl] - heptanoic acid; 7 - [ - 3 - hydroxy - 2 - (3 - hydroxyoctanyl) - 5 - oxocyclopentyl] - heptanoic acid; 7 - [3, 5 - dihydroxy - 2 - (3 - hydroxy - 1 - octenyl) - cyclopentyl] - heptanoic acid; 7 - [3 - hydroxy - 2 - (3 - hydroxy - 1, 5 - octadienyl) - 5 - oxocyclopentyl] - 5 heptenoic acid; and 7 - (3, 5 - dihydroxy - 2 - (3 - hydroxy - 1, 5 - octadienyl) - cyclopentyl) - 5 - heptenoic acid. |
