发明名称 |
PGC-1 isoforms and uses therefor |
摘要 |
The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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申请公布号 |
US7250283(B2) |
申请公布日期 |
2007.07.31 |
申请号 |
US20040482094 |
申请日期 |
2004.07.20 |
申请人 |
DANA-FARBER CANCER INSTITUTE |
发明人 |
SPIEGELMAN BRUCE M.;ADELMANT GUILLAUME;PUIGSERVER PERE |
分类号 |
C12N1/20;G01N33/50;A61K38/00;A61K45/00;A61P1/16;A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P15/00;A61P19/08;A61P21/00;A61P35/00;C07H21/04;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/02;C12N15/00;C12N15/09;C12P21/02;C12Q1/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;G01N33/68 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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