ANALOGUES OR DERIVATIVES OF QUERCETIN (PRODRUGS)

摘要

Novel carbamate ester analogues or derivatives of Quercetin (prodrugs) havin g a structural formula I are provided which have enhanced aqueous solubility a nd which are especially suitable for use as biodegradable prodrugs in pharmaceutical compositions formulated for clinical use: <IMG> or a pharmaceutically acceptable salt thereof, wherein one of R1, R2, R3, R 4 and R5 is an amino acid carbamate group CONHCH(R6)CO2H and the remainder are each hydrogen, and wherein R6 is hydrogen or C1-4 lower alkyl.