A BETA 1-42 SPECIFIC MONOCLONAL ANTIBODIES WITH THERAPEUTIC PROPERTIES

摘要

The present invention is related to methods and compositions for the
therapeutic and diagnostic use in the treatment of diseases and disorders
which are caused by or associated with amyloid or amyloid-like proteins
including amyloidosis, a group of disorders and abnormalities associated with
amyloid protein such as Alzheimer''s disease. The present invention provides
novel methods and compositions comprising highly specific and highly effective
antibodies having the ability to specifically recognize and bind to specific
epitopes from a range of .beta.-amyloid proteins. The antibodies enabled by
the teaching of the present invention are particularly useful for the
treatment of diseases and disorders which are caused by or associated with
amyloid or amyloid-like proteins including amyloidosis, a group of diseases
and disorders associated with amyloid plaque formation including secondary
amyloidosis and age-related amyloidosis including, but not limited to,
neurological disorders such as Alzheimer''s Disease (AD).