| 发明名称 |
Methods for the Preparation, Isolation and Purification of Epothilone B, and X-Ray Crystal Structures of Epothilone B |
| 摘要 |
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
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| 申请公布号 |
US2007122891(A1) |
申请公布日期 |
2007.05.31 |
| 申请号 |
US20070669268 |
申请日期 |
2007.01.31 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BENIGNI DANIEL;STANKAVAGE ROBERT;CHIANG SHU-JEN;HOU HSING;EAGAN BRUCE;GU DENNIS;HOU DAVID;MINTZMYER LES;TULLY THOMAS P.;DAVIS BRIAN L.;HARGRO IVAN;MASCARI MARK;GALVIN GABRIEL;STEIN GREGORY;MCCONLOGUE CARY W.;COMEZOGLU FAHRI T. |
| 分类号 |
C12P17/00;C12P17/02;A61K;C07D417/02;C07D417/06;C07D493/00;C07D493/04;C12N1/20;C12N5/06;C12N9/52;C12P17/14;C12P17/16;C12P17/18 |
主分类号 |
C12P17/00 |
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