发明名称 |
Malonamide derivatives blocking the activity of gamasecretase |
摘要 |
The invention relates to malonamide derivatives of formula wherein each of the variables are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates and diastereomeric mixtures thereof. These compounds are gamma-secretase inhibitors and may be used for the treatment of Alzheimer's disease. |
申请公布号 |
ZA200601989(B) |
申请公布日期 |
2007.05.30 |
申请号 |
ZA20060001989 |
申请日期 |
2006.03.08 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
FLOHR, ALEXANDER;JAKOB-ROETNE, ROLAND;PETERS, JENS-UWE;GALLEY, GUIDO;KITAS, ERIC ARGIRIOS;WOSTL, WOLFGANG |
分类号 |
A61K;A61K31/335;A61K31/55;A61K31/5513;C07D;C07D223/16;C07D223/20;C07D243/24;C07D273/00;C07D313/14 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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