发明名称 |
Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs |
摘要 |
The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.
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申请公布号 |
US7202348(B2) |
申请公布日期 |
2007.04.10 |
申请号 |
US20020255462 |
申请日期 |
2002.09.26 |
申请人 |
THE UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES |
发明人 |
OWENS SAMUEL M.;CARROLL FRANK IVY;ABRAHAM PHILIP |
分类号 |
C07K16/44;C07C217/60;C07C233/18 |
主分类号 |
C07K16/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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