发明名称 |
4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOL-2-ONES AND 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOL-2-ONES AND RELATED COMPOUNDS |
摘要 |
Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha<SUB>2B </SUB>and/or alpha<SUB>2C </SUB>adrenergic receptors in preference over alpha<SUB>2A </SUB>adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha<SUB>2B </SUB>adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.
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申请公布号 |
US2007072926(A1) |
申请公布日期 |
2007.03.29 |
申请号 |
US20060555831 |
申请日期 |
2006.11.02 |
申请人 |
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发明人 |
CHOW KEN;HEIDELBAUGH TODD M.;GIL DANIEL W.;GARST MICHAEL E.;WHEELER LARRY A. |
分类号 |
A61K31/4166 |
主分类号 |
A61K31/4166 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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