发明名称 |
SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION. |
摘要 |
<p>The invention provides certain acylthiourea derivatives and pharmaceutically acceptable salts thereof. These compounds possess potent antiviral activity. The invention particularly provides compounds that are potent and/or selective inhibitors of hepatitis C virus replication. The invention also provides pharmaceutical compositions containing a compound of the invention and at least one pharmaceutically acceptable excipient and packaged pharmaceutical compositions comprising such a pharmaceutical composition in a container together with instructions for using the composition to treat a viral infection. The invention further comprises a method of inhibiting hepatitis C virus replication by contacting a compound of the invention with a cell that is infected by hepatitis C virus and a method of treating or preventing hepatitis C viral infection by administering an amount of a compound of the invention to a subject in need thereof.</p> |
申请公布号 |
MXPA06013374(A) |
申请公布日期 |
2007.03.01 |
申请号 |
MX2006PA13374 |
申请日期 |
2005.05.17 |
申请人 |
ACHILLION PHARMACEUTICALS, INC. |
发明人 |
DAWEI CHEN;MILIND DESHPANDE;ANDREW THURKAUF;AVINASH PHADKE;XIANGZHU WANG;YIPING SHEN;CUIXIAN LIU;JESSE QUINN;JUNKO OHKANDA;SHOUMING LI |
分类号 |
A61P31/12;C07D249/06;A61K31/17;A61K31/277;A61K31/341;A61K31/343;A61K31/351;A61K31/352;A61K31/381;A61K31/415;A61K31/4155;A61K31/4164;A61K31/4192;A61K31/42;A61K31/421;A61K31/423;A61K31/4245;A61K31/426;A61K31/428;A61K31/429;A61K31/433;A61K31/4355;A61K31/437;A61K31/4375;A61K31/4406;A61K31/4412;A61K31/443;A61K31/445;A61K31/455;A61K31/47;A61K31/4725;A61K31/496;A61K31/498;A61K31/50;A61K31/505;A61K31/506;A61K31/519;A61K31/53;A61K31/5375;A61K31/5377;C07C335/18;C07C335/20;C07C335/26;C07D211/20;C07D211/22;C07D211/46;C07D211/60;C07D211/64;C07D211/78;C07D213/56;C07D213/75;C07D213/82;C07D213/84;C07D213/85;C07D215/54;C07D231/14;C07D233/54;C07D233/60;C07D233/90;C07D237/24;C07D239/28;C07D241/24;C07D241/42;C07D241/44;C07D253/06;C07D253/07;C07D261/18;C07D263/34;C07D263/58;C07D265/30;C07D271/12;C07D277/20;C07D277/56;C07D277/68;C07D285/06;C07D295/10;C07D295/14;C07D295/15;C07D307/68;C07D307/84;C07D307/85;C07D309/38;C07D311/04;C07D311/58;C07D333/38;C07D401/04;C07D401/12;C07D405/04;C07D405/12;C07D405/14;C07D409/04;C07D409/12;C07D413/12;C07D417/04;C07D417/12;C07D417/14;C07D419/12;C07D471/04;C07D487/04;C07D491/04;C07D491/048;C07D495/04;C07D513/04 |
主分类号 |
A61P31/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|