MODULATORY LIPOSOMAL CONTROLLED RELEASE SYSTEM (MLCRS): A NEW DOSAGE FORM FOR ENCAPSULATING ANTICANCER DRUGS BASED ON LIPOSOMAL AND DENDRIMER TECHNOLOGY

摘要

Liposomes composed either of natural or synthetic phospholipids or either lipids or lipoamines or lipids. A dendrimer - anticancer drug complex or dendrimer - bioactive product complex encapsulated or attached to the lipid bilayers of the liposomes lead to a new liposomal form called Modulatory Liposomal Controlled Release System (MLCRS). This new liposomal was characterized physicochemicaly and the release rate of the anticancer drug doxorubicin was studied and corellated to the increase of the therapeutic index of doxorubicin. The advantage of this limposomal system is the modulation of the controlles release of the anticancer drug that is fundamental for the improvement of the pharmacokinetic parameters and its pharmacological evaluation. The present invention is suitable for use for the treatment of cancer.