| 摘要 |
This invention provides methods for treating or reducing an incidence of a disease, disorder, or symptom in a subject, wherein the disease, disorder, or symptom comprises a dysregulated apoptosis in a neuron, comprising contacting the subj ect with a compound or composition that alters an activity or expression of an ARTS (Apoptosis Related Protein in the TGF-ß Signaling Pathway) protein. This invention also provides methods for determining predisposition or susceptibility of a subject to the disease, disorder, or symptom, and methods for identifying a compound or composition useful for prophylactic or therapeutic treatment of schizophrenia, comprising detecting ARTS protein activity or expression or determining a sequence of a gene encoding an ARTS protein.
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