PRIMER SET, PRIMER AND PROBE FOR DETECTING POLYMORPHISM OF DRUG METABOLIC ENZYME CYP1A2 GENE AND EXAMINATION MEDICINE FOR METABOLIC ACTIVITY OF THE SAME ENZYME AND METHOD FOR EXAMINING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide an examination medicine for detecting genetic polymorphism associated with the metabolic ability of CYP1A2 before administering a drug metabolized with a drug metabolic enzyme CYP1A2 including a bronchodilator theophylline as a medicine and administering the drug metabolized with the CYP1A2 in an amount corresponding to each patient and thereby avoiding adverse effects with the drug. SOLUTION: A primer set, a primer and a probe detect SNPs (single nucleotide polymorphism) in the 125th, 1130th or 1367th base on the CYP1A2 gene associated with the metabolic ability of the drug metabolic enzyme CYP1A2. Furthermore, the examination medicine for the metabolic activity of the enzyme and a method for examining the same are obtained. Thereby, the drug metabolic disorder is judged on the basis of the detected SNPs and the drug such as the theophylline in the amount corresponding to the metabolic activity of the CYP1A2 of each patient can then be administered to avoid the adverse effects of the drug such as the theophylline. COPYRIGHT: (C)2007,JPO&INPIT