IMIDAZO[1,5-A]PYRIMIDO[5,4-D][1]BENZAZEPINE DERIVATIVES

摘要

THE PRESENT INVENTION RELATES TO COMPOUNDS OF FORMULA (FORMULA)WHEREIN R1IS HALOGEN OR LOWER ALKYL;R2IS HYDROGEN, LOWER ALKYL, CYCLOALKYL, -(CH2)m-PHENYL, WHEREIN THE PHENYL RING MAY BE SUBSTITUTED BY LOWER ALKOXY, OR IS -(CH2)m-INDOLYL;R3IS -C(O)O-LOWER ALKYL, -C(O)OH, OR A FIVE MEMBERED HETEROAROMATIC GROUP, WHICH RINGS MAY BE SUBSTITUTED BY LOWER ALKYL OR CYCLOALKYL;nIS 0, 1 OR 2;mIS 0, 1 OR 2;AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS. IT HAS BEEN FOUND THAT THIS CLASS OF COMPOUNDS SHOW HIGH AFFINITY AND SELECTIVITY FOR GABA A (ALPHA)5 RECEPTOR BINDING SITES AND MIGHT BE USEFUL FOR THE TREATMENT OF COGNITIVE ENHANCER OR OF COGNITIVE DISORDERS LIKE ALZHEIMER'S DISEASE.