发明名称 |
USE OF APOPTOSIS INHIBITING COMPOUNDS IN DEGENERATIVE NEUROLOGICAL DISORDERS |
摘要 |
The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of intracellular protein aggregates. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding an inhibitor of apoptosis protein (IAP) to cells in the region. |
申请公布号 |
WO2006047250(A3) |
申请公布日期 |
2006.11.23 |
申请号 |
WO2005US37822 |
申请日期 |
2005.10.21 |
申请人 |
NEUROLOGIX, INC.;KAPLITT, MICHAEL;MOUSSATOV, SERGUEI |
发明人 |
KAPLITT, MICHAEL;MOUSSATOV, SERGUEI |
分类号 |
A61P25/28;A61K48/00;C07K19/00;C12N15/86 |
主分类号 |
A61P25/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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